A cattle yard, if I recall right. In all the places I'm aware of ADE happening, it is an acute, mostly cytokine-driven event," he told MedPage Today. In laymans terms, it was explained to me like this–, after the first shot: “Hey, who are you and why are you in my house?” There is real world evidence for this. https://www.medrxiv.org/content/10.1101/2021.02.08.21251362v1. ADE with anti-S might be less of a problem than VAH when antibody responses to vaccines wane to sub-neutralising levels and new variants/future mutations have the potential to exacerbate this. But variants are what viruses do. However our dr say shouldn’t be a problem. https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2021.26.5.2100092. Tweet! I really wonder what people like you think you are doing. I agree with us you suspiciously that in Israel the health insurance funds have limited the ability to measure the value of antibodies, but they propose to make additional doses to everyone vaccinated after 6 months .. in other words, apparently the pgfiser knowing about the drop in antibodies, is trying to prevent the appearance of hell by raising antibodies at the expense of an additional dose, it means that the vaccinated must receive a new dose all the time, does it not say that the MRnI vaccine does not give cellular tissue immunity ? … these have been running for a long time and crunching the numbers doesn’t look all that great. You are absolutely unbelievable (in more senses than one!). It’ll be interesting when/if we can compare actual data in terms of severity of disease in vaccinated people who’ve become infected vs. non-vaccinated people who’ve been “reinfected.” Even more interesting (and important, I think) will be the data on severity in people (from either group) who’ve been “reinfected” by B.351, P.1, or any mutant yet to come . 48 hours of hell, but it was worth it. So maybe this isn’t an apples-to-apples comparison. c) Historical and literary rubbish, https://www.nationalarchives.gov.uk/education/resources/christmas-is-cancelled/. Combined with the fact that AZ’s now-reported long-term efficacy for a single dose is not statistically significant from the two-dose efficacy … and I dunno. https://www.medrxiv.org/content/10.1101/2020.08.04.20167932v4.full.pdf. 9) The specificity of SARS-CoV-2 reverse transcriptase polymerase chain reaction testing (“RT-PCR”) is: a) Invariably greater than 99% in all laboratories around the world But the vaccines were still effective in the older groups – so having fewer side effects doesn’t mean the vaccine is ineffective, even if the immune system is not responding as obviously. If you are younger than 40, it seems you can skip the shot and take the risk of Covid. This is the most pessimistic scenario that cannot be ruled out. Unless I am mistaken, all other vaccines reports are the studies of the effectiveness of the serum of vaccinated people on different virus variants in the lab settings. Surely this is the objective of any vaccine…. Ade Olujohungbe. After vaccinated children developed more severe illness, the vaccine was withdrawn. That's the way of getting virus into cells that it ordinarily would not infect," Bloom said. The build up of cases in published Pfizer P3 trial (Derek had the picture in some earlier post) showed the marked brake after about two weeks after the first dose, at about time of the second shot. Lowe, Montrell rush for 4 yards to the PUR38 (Bailey, Rodney). Probably the infection rates are lower than for the population as a whole, but there’s no reason to think the percentage of asymptomatic cases (about 40%) should be an underestimate. There was a press release about them on July 1st, when they had been in progress for at least 28 days. Lying and misleading people like an accidental half dose regime of a certain vaccine gives 90% efficacy to keep up with the Jonses over at Moderna and Pfizer. Why aren’t we learning from their experiences? I’ve seen several immunologists comment that post-infection immunity is always more effective than that obtained by vaccination. Derek Lowe, December 18, 2020) So, I fail to see any solid support for Wakefield’s claim here either. 603 votes, 90 comments. Unfortunately for vaccine developers, spike proteins are liable to spring from their stubby prefusion shape into their elongated postfusion form on a hair-trigger. “The opinion of Professor Iwasaki, a leading expert in immunology (Yale University, USA) on the single dose for those who have already had covid . The US might look into this eventually, if they can work out a way to maximize corporate profits, without the necessity of taxing the rich. Pfizer’s numbers were slightly lower. Dengvaxia showed initial efficacy too, look what happened there. But you’re right — it does, suggest that vaccination protects against serious disease, even among the high-risk elderly. I think this may be the main paper that set off the ADE social media frenzy. The AE %s are lower in older people than younger, but the theoretical reason for that is because they have less of an immunogenic response to the vaccines. Prescribe accordingly, ranging from NYstatin to Pull Yourself Together Man delivered via WhatsApp. Easy money. Publish! Blaming the viral vector didn’t make sense. Derek Lowe, December 18, 2020). b) A political statement What do you think? Do we have actual data (i.e., numbers) on the extent to which the vaccines might prevent infection / transmission? Is Institut Pasteur the only lab capable of doing this? The vaccine was associated with immune complex formation that caused lung obstruction and enhanced respiratory disease, pretty much stalling RSV vaccine development. Reduced TCR signaling intensity (Although I’m becoming increasingly concerned that it may not matter much anymore, because everything we thought we knew about vaccine efficacy, and probably most of what we thought we knew about reinfection, will be obsolete within a few weeks as B.1.1.7 and B.1351 [just for starters — B.1.525 has now joined the club] become increasingly dominant, and p.1 is out there, too]. a VAST minority of people. My first Pfizer shot made me pretty sick. I thought they might have compared severe disease rates between vaccinated infected vs unvaccinated infected to come up with the 92% rate reduction figure. Reduced antitumor responses, Regulatory T cells That in itself is excellent, but it is not no cases. I don’t recall if the Astra/Zeneca one introduced those amino acid changes as well or not. I guess I owe an apology (as do the editors of “Bestflife”). ADE and Coronaviruses. https://www.ema.europa.eu/en/documents/rmp-summary/comirnaty-epar-risk-management-plan_en.pdf Derek Lowe has only this to say about it "How about the human clinical trials? I’ve also read that the fact that convalescent plasma doesn’t seem to lead to enhancement is a source of reassurance. It seems like a situation the likes of AZ would not rush into without data to direct their tread, so I figure it must exist. “It is an open question whether the current vaccines at least reduce infections and transmissions, the initial data seems to support that but much less than the 95% reduction for severe disease.”. Thank you both of you for your helpful replies! Some people are probably getting vaccines that got too warm, so maybe the vaccines are no longer effective. (google says it’s Instrument Flight Rules). But I didn’t realize that they hadn’t stabilized the spike. “Lying and misleading people like an accidental half dose regime of a certain vaccine gives 90% efficacy to keep up with the Jonses over at Moderna and Pfizer.”. You’ll also be watching your clinical trial data and (indeed) the eventual real-world rollout for any signs of this as well. On one end, the AstraZeneca/Oxford vaccine appears to lose potency to a degree that the South African government stopped vaccinating with it entirely. No one is going to go through this rigamarole. I can’t be bothered with the HIT and transmission debates, because my only concern is that immunity reduces hospitalizations and deaths to such a level that we can get on with normal life. I haven´t read all comments so sorry if I repeat this question: I don`t see in your article the reasons you get so many queries about ADE. This seems completely irresponsible to report. As found above, that will result in T-cell recognition epitopes all over the Spike protein. (Source: Ontario Government website: COVID-19 update – data and details – archived daily epidemiologic summaries), the impression is that no one has read that the drop in the level of antibodies and the beginning of a possible vade 6 months after the second injection, as declare the conclusion when in Israel 3 months have passed since the beginning of vaccinations !! Has anyone, AFTER INFLUENZA VACCINATION, TRIED AN ANTIBODY CHECK TO GET AN ADDITIONAL VACCINATION? It seems that Novavax and Janssen are additionally mutating protease target sites that contribute to a post-fusion confirmation. I had mine a few days ago and nothing really to report. The news about vaccine efficacy against these variants is actually not as bad as you might have thought, based on some news reports. Time limit is exhausted. Given AstraZeneca’s relatively mediocre performance in reducing symptomatic cases, I think it would be surprising if it were as effective as the mRNA vaccines in reducing overall infections. But they said that cases after vaccination were likely to be exceedingly rare, possibly the result of an unknown predisposition in some people to react to the vaccine by developing an immune response that destroys their platelets. . During period of elevated risk, I plan on adjunct ivermectin to S vax immune response . The disorder has occurred, rarely, in people who received other inoculations, particularly the measles-mumps-rubella one.”. . All content is Derek’s own, and he does not in any way speak for his employer. The last time I had flu was the 2009 pandemic H1N1 “swine flu”, and I really do not remember it being that bad – I threw up a couple times, felt sick and woozy for two or three days, then was back to normal. I will refer to two situations: 1) Israel, and 2) nursing homes in Ontario. So here’s the short version: no sign of ADE during the preclinical animal studies. I think Derek Lowe is right that there is no indication yet of ADE in COVID-19 vaccines, that vaccines reduce the disease, and that a prudent person might accept a vaccine for himself. March 16, 2021. Arguably tried that out for size already using this blog’s reply option? I’m suspicious that people that don’t have side effects didn’t get a good vaccine – as it wasn’t stored at the right temperature. Does that make sense … or it doesn’t make any difference? Furthermore, ADE is an acute problem, and it can be very dramatic. Antibodies can also cause aggregation, sticking viral particles in clumps that can’t function as they would otherwise. Thanks again! What exactly is ADE? Your date for the start of research is incorrect. your thoughts gentlemen scientists, https://www.timesofisrael.com/ministers-said-asked-to-okay-2-1-billion-for-more-vaccines-keep-lid-on-matter/. Clearly the vaccines do nothing at all. New worshippers always welcome at the Consecrated Church of Ruling Clinical Thought. d) 430K True negatives, https://www.bmj.com/content/369/bmj.m1808/rapid-responses Thank you for your time. https://apnews.com/article/pandemics-coronavirus-vaccine-coronavirus-pandemic-africa-south-africa-2af2127cd0b595b7c4b73a776c4b3b23. 24) The UK Conservative government has responded to a request made in the House of Commons on 2 November 2020 by the Chairman of the Conservative Party 1922 Committee to, “Publish a full impact assessment, setting out the cost of the lockdown in terms of the jobs that will be lost, the businesses that will fail, the enormous toll on people’s mental health and other aspects of their health…” by: a) Compiling a “balance sheet” It simply reacts to been exposed to a new antigen and slowly (thankfully, or we would all die because of cytokine storm) build up the response. Throughout the pandemic, scientists have been looking for ADE associated with SARS-CoV-2, but so far they haven't found any cases of it, noted Lichty. Well intentioned, but wrong all along. And that would mean completely unacceptable risks in that human population. c) The current democratically elected UK government will never compile a balance sheet, https://www.theyworkforyou.com/debates/?id=2020-11-02c.24.0&s=graham+brady#g35.1. I was speaking to one of the other people on this site who said that his aunt and 6 others in the care home who had had their first AZ dose tested positive for Covid, but none of them experience any symptoms at all. You seem to know quite a bit on this topic also. I’ve never seen any informed discussion of what led Oxford to go in a different direction on the spike modification. “It would help if people like Chris Phillips would not spread lies about what I said. While efficacy against symptomatic Covid is against the South African variant is indeed diminished, protection from severe disease remains the same – very high independent of age, only increasing with time after vaccine administration. I’m going to get my shot at a hospital that seems to have plenty of vaccine. Claim: COVID-19 mRNA vaccines are "experimental gene therapy," don't provide immunity to the disease, and do "not meet the CDC’s own definition of a vaccine." Tens of thousands of people have had both doses for more than six months by now. We keep being told that were not protectected for 2 to 3 weeks after vaccination what is it that allowed me to battle and overcome the infection in 5 days and out of isolation in 10 days . But the concerns about ADE with COVID-19 vaccines have resurfaced with the emergency of virus variants. it is deeply concerning that we dont see more data on this matter. https://www.whatdotheyknow.com/request/704591/response/1677888/attach/2/1873%20FOI%20Information%20on%20RT%20PCR%20assays%20used%20by%20PHE%20labs.pdf?cookie_passthrough=1. Like, examples of how that game works? The existence of reinfections – and even the occasional severe case – doesn’t disprove the general picture that prior infection does provide immune protection (though the exact degree/duration is uncertain). Some people have no side effects. Derek Lowe's commentary on drug discovery and the pharma industry. . Although I trust that leaked data as little as the massive CIs suggest that we should, I keep wondering why the AZ vaccine is performing a little sub-par in general compared to all other vaccines. Chemical and antifungal characterisation carried out in New York State Department of Health laboratories by a highly experienced microbiologist in her sixties and a just as highly experienced chemist in her fifties. It is noted that an urgent meeting on this issue was supposed to take place today, but it was postponed to Monday in connection with the demand of the head of the Ministry of Defense Benny Gantz to explain the need to allocate such a large amount in conditions when more than half of the population has already been vaccinated against COVID-19, and the available stocks of vaccines enough. Very helpful post. OTOH, there is a ton of individual variation. Brees, Drew pass complete to Sutherland, V. for 10 yards to the OSU49, 1ST DOWN PUR, out-of-bounds (Ross, Derek). As long as the first and second cases are separated by 3 months or more, the contamination of the results by persistent PCR positives should be minimal. I agree with you that “reduc[ing] hospitalizations and deaths to such a level that we can get on with normal life” should be the goal, even though we don’t usually hear that talked about very much among most “mainstream” commentators and health/public policy operatives. You should seek some medical guidance on when you should get vaccinated. We are, and I am very, very happy to be able to say this, seeing exactly the reverse. First isolated in 1950 from soil sample taken from a farmyard in New York state. Perhaps that was a different commenter? Son of North Midland hilltop parish. . Ten to make and the match to win — b) Disagree Member of the Fabian Society. Extreme chills (teeth chattering) all night long, followed by headache and extreme fatigue. That December post has links to times this has been seen with vaccinations, too: there has been one RSV vaccine candidate and one measles vaccine candidate that have certainly shown this problem (the antibodies they generated made the next exposure even worse). Eran Segal seems to be the one to follow on twitter: So it has a big “cushion,” so to speak, to work with in terms of becoming more contagious and more virulent, before it begins to threaten its own survival. Right now, we don’t know squat about any of this, anecdotal case reports notwithstanding. . Not “mild”, means going into hospital. That’s exactly the kind of study we need, only on a nationwide basis. Initial efficacy could potentially still backfire and there is no current evidence available that provides me with any comfort that this will not happen, as vaccination is irreversible I’ll happily take the much better known risks of natural infection. . And I remain skeptical that there will just be endless new variants. After all, upwards of 30% of the US population is estimated to have been exposed, even though only a fraction of that number qualify as “official” cases. https://www.bmj.com/content/360/bmj.j5845/rapid-responses. Many of the people who are contacting me sound a lot more worried than I would have thought, so that prompts me to follow up on the post I did on the subject back in December. The CFR is currently running at just shy of 3% on PCR confirmed cases (I’m wondering what is the cause of the high CFR in the UK; I doubt that we’re worse at detecting cases than the rest of Europe), and that’s an underestimate of deaths. The only reason I can think of for this elongation would be further stabilization of the spike in its prefusion configuration. Escape mutations seem to be growing resistance in Europe and UK concerning the vaccine! A 75 year old resident of Ontario, Canada Journal and report from there ignores cellular,... 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